Effect of upper body venoarterial ECMO on systemic hemodynamics and oxygenation: A computational study.

ABSTRACT:

Background

This study seeks to quantify the effects of upper body veno-arterial extracorporeal membrane oxygenation (VA ECMO) on the anatomical distribution of oxygen delivery in the setting of hypoxic respiratory failure and provide new insights that will guide clinical use of this support strategy to bridge patients to lung transplant.

Methods

Employing a patient-specific vascular geometry and a quantitative model of oxygen transport, computational simulations were performed to determine hemodynamics and oxygen delivery in the ascending and descending aorta, left and right coronary arteries, and great vessels during upper body VA ECMO support. Oxygen content in ECMO circuit blood flow was varied while considering different degrees of lung failure severity. Using lumped par

SUBMITTER: Moradi H 

PROVIDER: S-EPMC11584320 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature