Membrane transporters modulating the toxicity of arsenic, cadmium, and mercury in human cells.

ABSTRACT: Non-essential metals are extremely toxic to living organisms, posing significant health risks, particularly in developing nations where they are a major contributor to illness and death. Although their toxicity is widely acknowledged, the mechanisms by which they are regulated within human cells remain incompletely understood. Specifically, the role of membrane transporters in mediating heavy metal toxicity is not well comprehended. Our study demonstrates how specific transporters can modulate the toxicity of cadmium, mercury, and the metalloid arsenic in human cells. Using CRISPR/Cas9 loss-of-function screens, we found that the multidrug resistance protein MRP1/ABCC1 provided protection against toxicity induced by arsenic and mercury. In addition, we found that SLC39A14 and SLC30A1 increa

SUBMITTER: Ferdigg A 

PROVIDER: S-EPMC11584324 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature