Novel Insights Into the Causal Effects and Shared Genetics Between Body Fat and Parkinson Disease.

ABSTRACT:

Aims

Existing observational studies examining the effect of body fat on the risk of Parkinson disease (PD) have yielded inconsistent results. We aimed to investigate this causal relationship at the genetic level.

Methods

We employed two-sample Mendelian randomization (TSMR) to investigate the causal effects of body fat on PD, with multiple sex-specific body fat measures being involved. We performed Bayesian colocalization analysis and cross-trait meta-analysis to reveal pleiotropic genomic loci shared between body mass index (BMI) and PD. Finally, we used the MAGMA tool to perform tissue enrichment analysis of the genome-wide association study hits of BMI.

Results

TSMR analysis suggests that except waist circumference, higher measures of body fatness are associated wi

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11584348 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature