Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity.

ABSTRACT:

Background and objectives

Gut dysbiosis that resulted from the alteration between host-microbe interaction might worsen obesity-induced systemic inflammation. Gut microbiota manipulation by supplementation of prebiotic inulin may reverse metabolic abnormalities and improve obesity. This study aimed to determine whether inulin supplementation improved intestinal microbiota and microbial functional pathways in children with obesity.

Methods

Children with obesity whose BMI above median + 2SDs were recruited to a randomized, double-blinded placebo-controlled study. The participants aged 7-15 years were assigned to inulin supplement extracted from Thai Jerusalem artichoke (intervention), maltodextrin (placebo), and dietary fiber advice groups. All participants received similar mo

SUBMITTER: Visuthranukul C 

PROVIDER: S-EPMC11584386 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature