Morphine-Driven m6A Epitranscriptomic Neuroadaptations in Primary Cortical Cultures.

ABSTRACT: Opioid overdose is the leading cause of accidental death in the United States and remains a major public health concern, despite significant resources aimed at combating opioid misuse. Neurobiological research to elucidate molecular and cellular consequences of opioid exposure is required to define avenues to explore for reversal of opioid-induced neuroadaptations. Opioids impart well-documented regulation of the transcriptome and epigenetic modifications in the brain, but opioid-induced epitranscriptomic posttranscriptional regulation of RNA is vastly understudied. N6-methyladenosine (m6A) RNA methylation is significantly enriched in the brain and involved in learning, memory, and reward. m6A modifications have not been studied in opioid use disorder, despite being the most common RNA mod

SUBMITTER: Dabrowski KR 

PROVIDER: S-EPMC11584444 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature