Neuroprotective Effect of a Multistrain Probiotic Mixture in SOD1^G93A Mice by Reducing SOD1 Aggregation and Targeting the Microbiota-Gut-Brain Axis.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the selective loss of motor neurons. A bidirectional communication system known as the "microbiota-gut-brain" axis has a regulatory function in neurodegenerative disorders. The impact of probiotics on ALS through the "microbiota-gut-brain" axis remains uncertain. A longitudinal investigation was conducted to examine the alterations in the structure of the ileum and colon in mutant superoxide dismutase 1 (SOD1^G93A) transgenic mice models of ALS by using immunofluorescence and Western blotting. Subsequently, the mice were administered a multistrain probiotic mixture (LBE) or vehicle orally, starting from 60 days of age until the terminal stage of the disease. The effects of these agents

SUBMITTER: Xin Z 

PROVIDER: S-EPMC11584480 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature