Investigation of cefiderocol resistance prevalence and resistance mechanisms in carbapenem-resistant <i>Pseudomonas aeruginosa</i>, Germany 2019-21.

ABSTRACT:

Background

Cefiderocol, a novel siderophore cephalosporin, is a promising therapeutic option for infections caused by multidrug-resistant Pseudomonas aeruginosa. We evaluated the activity of cefiderocol against carbapenem-resistant P. aeruginosa (Cr-Pa) isolates and investigated the potential mechanisms involved in resistance.

Methods

108 CR-Pa isolates collected from patients without prior exposure to the substance were studied. MICs of cefiderocol were determined by broth microdilution using iron-depleted cation-adjusted Mueller-Hinton broth. Whole genome sequencing was performed to investigate the potential resistance mechanisms by comparing resistant and susceptible P. aeruginosa isolates and identifying unique mutations in the resistant group.

Re

SUBMITTER: Kocer K 

PROVIDER: S-EPMC11584512 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature