ECGA: A web server to explore and analyze extrachromosomal gene in cancer.

ABSTRACT: Circular extrachromosomal DNA (ecDNA) plays a crucial role in the onset, progression, and evolution of many types of cancers, with dysregulated gene expression driven by ecDNA as a key mechanism. Although database resources for ecDNA are now available, a sophisticated web application dedicated to ecDNA gene analysis remains absent. Therefore, we developed ecDNA gene analyzer (ECGA). ECGA catalogues 23,274 unique ecDNA genes of 27 cancers across 27 tissues. ECGA also offers five specialized analysis tools: (1) 'Venn analysis' looks for overlaps between a given gene list and ecDNA genes; (2) 'Enrichment analysis' performs over-representation analysis and gene set enrichment analysis of input gene list within predefined ecDNA gene sets; (3) 'Target discovery' identifies upregulated ecDNA gene

SUBMITTER: Zhou N 

PROVIDER: S-EPMC11584521 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature