RIPK2 and lysosomal pathway: Unveiling a new mechanism for lung cancer metastasis.

ABSTRACT:

Background

This study aims to explore the role of RIPK2 in lung cancer metastasis and its potential mechanisms.

Methods

The expression levels of RIPK2 in lung cancer patients and cell lines were detected by immunohistochemistry, qRT-PCR, and Western blot. RIPK2 expression was knocked down using siRNA technology, and its effects on the proliferation, migration, and invasion capabilities of lung cancer cells were assessed through CCK-8, EdU, colony formation, and Transwell assays. Furthermore, by overexpressing RIPK2 and LAMP2, the regulatory effect of RIPK2 on the lysosomal pathway and its mechanism of action in lung cancer metastasis were investigated.

Results

The results showed that the expression of RIPK2 was significantly increased in lung cancer patients and cell

SUBMITTER: Liu W 

PROVIDER: S-EPMC11584686 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature