Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: A Mendelian randomization mediation analysis.

ABSTRACT:

Background

The etiological connection between intraocular pressure (IOP) and the risk of retinal vein occlusion (RVO) remains elusive, particularly regarding whether this risk emanates from the direct influence of elevated intraocular pressure (IOP), irrespective of the presence of primary open-angle glaucoma (POAG), or if it arises as a consequence of the sequelae of POAG. Therefore, we conducted a Mendelian Randomization (MR) mediation analysis to elucidate the mediating role of POAG in the association between IOP and RVO.

Methods

We identified 47 single-nucleotide polymorphisms (SNPs) associated with IOP (P-value < 5 × 10^-8) leveraging data from a genome-wide association study (GWAS) (N = 97,653) obtained from the UK Biobank and 50 SNPs associated with POAG (P-

SUBMITTER: Katsimpris A 

PROVIDER: S-EPMC11584727 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature