Viral-mediated increased hippocampal neurogranin modulate synapses at one month in a rat model of controlled cortical impact.

ABSTRACT: Reductions of neurogranin (Ng), a calcium-sensitive calmodulin-binding protein, result in significant impairment across various hippocampal-dependent learning and memory tasks. Conversely, increasing levels of Ng facilitates synaptic plasticity, increases synaptogenesis and boosts cognitive abilities. Controlled cortical impact (CCI), an experimental traumatic brain injury (TBI) model, results in significantly reduced hippocampal Ng protein expression up to 4 weeks post-injury, supporting a strategy to increase Ng to improve function. In this study, hippocampal Ng expression was increased in adult, male Sham and CCI injured animals using intraparenchymal injection of adeno-associated virus (AAV) 30 min post-injury, thereby also affording the ability to differentiate endogenous and exogenou

SUBMITTER: Svirsky SE 

PROVIDER: S-EPMC11584851 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature