Causal associations between sexually transmitted infections, depression, and self-harm: a mendelian randomization and cross-sectional study.

ABSTRACT:

Background

The causal relationships between sexually transmitted infections, depression, and self-harm remain unclear.

Methods

We executed various Mendelian Randomization (MR) analyses. At the same time, a cross-sectional analysis from NHANES was used for verification and an enrichment analysis was also utilized to explore the potential common gene functions.

Results

We found that STIs may have a potential causal effect on depression (P = 0.002) and self-harm (P = 0.003). Conversely, self-harm has been identified as a risk factor for the acquisition of STIs (P = 0.006), while there is no evidence to support an effect of depression on STIs. Furthermore, mediation MR indicated that monocyte absolute count played a mediating role in the association between STIs and depre

SUBMITTER: Peng S 

PROVIDER: S-EPMC11585095 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature