Impact of gut microbiota on metabolic syndrome and its comprising traits: a two-sample mendelian randomization study.

ABSTRACT:

Background

The prevalence of metabolic syndrome is on the rise globally. Understanding the etiology and discovering potential treatment target have become a priority. Observational data have linked gut microbiota with metabolic syndrome and its comprising traits. However, whether these relations underlie causal effects remains unclear.

Methods

Using Inver Variance Weighted (IVW) as primary analysis method, we performed two-sample Mendelian Randomization (MR) analyses to explore the causal relationship between gut microbiota and metabolic syndrome with its comprising traits. Methods including MR-Egger regression, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), Weighted Mode, and Weighted Median were chosen for additional MR analysis to test the robustness of MR results. C

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11585155 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature