Gut-derived IL-13 contributes to growth via promoting hepatic IGF-1 production.

ABSTRACT:

Background

The gut microbiota has a profound effect on immunity and metabolic status of the host, which has increasingly attracted research communities. However, the intrinsic mechanism underlying the interplay among these three aspects remains unclear.

Results

Different immune states were established via shaping the population structure of gut microbiota with antibacterial agents. The gut microbiota population structures altered with the subtherapeutic level of antibacterial agents facilitated growth phenotype in both piglets and infant mice. Notably, increased colonization of Prevotella copri was observed in the intestinal microbiota, which shifted the immune balance from a CD4⁺ T cell-dominated population toward a T helper 2 cell (Th2) phenotype, accompanied by

SUBMITTER: Ma N 

PROVIDER: S-EPMC11585157 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature