Multiscale modelling of bioprocess dynamics and cellular growth.

ABSTRACT:

Background

Fermentation processes are essential for the production of small molecules, heterologous proteins and other commercially important products. Traditional bioprocess optimisation relies on phenomenological models that focus on macroscale variables like biomass growth and protein yield. However, these models often fail to consider the crucial link between macroscale dynamics and the intracellular activities that drive metabolism and proteins synthesis.

Results

We introduce a multiscale model that not only captures batch bioreactor dynamics but also incorporates a coarse-grained approach to key intracellular processes such as gene expression, ribosome allocation and growth. Our model accurately fits biomass and substrate data across various Escherichia coli strains, e

SUBMITTER: Mahnert C 

PROVIDER: S-EPMC11585165 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature