Association of circulating ketone bodies with cognitive performance and dementia in the Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Introduction

Growing interest centers on the association between circulating ketone bodies (KB) and cognitive function, notably in aging and neurodegenerative diseases.

Methods

Associations of plasma KB with incident dementia and cognitive performances were examined among Multi-Ethnic Study of Atherosclerosis (MESA) participants. KB were measured using plasma samples collected following an overnight fasting at Exam 1 (2000-02) and detailed cognitive testing at Exam 5 (2010-2012, N = 4392), Exam 6 (2016-2018, N = 1838), and in MESA-MIND (2019-2021, N = 2060).

Results

Over 16.7 years, a doubling of total KB was associated with a greater risk of incident dementia (hazard ratio [HR]: 1.14 [1.04-1.29]). Higher total KB was associated with worse cogniti

SUBMITTER: Chevli PA 

PROVIDER: S-EPMC11585168 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature