Exploratory DNA methylation analysis in post-mortem heart tissue of sudden unexplained death.

ABSTRACT:

Background

Sudden unexplained death (SUD) is a devastating event in the young. Despite efforts to identify causal genetic variants, many cases remain unexplained after genetic screening. This study aimed to investigate an alternative potential contributor to SUD by studying the human methylome using the MethylationEPIC v2.0 BeadChip kit in heart tissue from SUD cases. The genome-wide methylation results of the SUD cases were compared to the results of a control cohort. The SUD cases were divided into three main groups based on their autopsy reports, heart morphology and histopathology (primaryN: macroscopically and histologically normal heart; primaryCM: macroscopically or histologically abnormal heart, suspected cardiomyopathies; and secondary: myocardial damage due to other under

SUBMITTER: Sutter C 

PROVIDER: S-EPMC11585171 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature