Effect of Tricin on cardiomyocyte damage caused by diabetic cardiomyopathy (DCM).

ABSTRACT:

Objectives

Flavonoid compounds exhibit remarkable antioxidant and anti-inflammatory properties in DCM and various other diseases. However, the specific mechanisms by which Tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone, exerts its effects in the context of DCM remain to be elucidated.

Methods

Rat H9C2 cells were cultured and subjected to high glucose conditions to establish a DCM cell model. Tricin was administered in varying concentrations to evaluate its effects on cellular oxidative stress markers, including ROS, LDH, and SOD. Additionally, the levels of inflammatory cytokines TNF-α, IL-1β, and IL-6, as well as the expression of TLR4, MYD88, and p-NF-κB, were assessed through ELISA and Western blotting.

Results

Tricin treatment significantly ameliorated high gluc

SUBMITTER: Yu R 

PROVIDER: S-EPMC11585224 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature