BindCompare: a novel integrated protein-nucleic acid binding analysis platform.

ABSTRACT:

Summary

Advanced genomic technologies have generated thousands of protein-nucleic acid binding datasets that have the potential to identify testable gene regulatory network (GRNs) models governed by combinatorial associations between factors. Transcription factors (TFs), and RNA binding proteins (RBPs) are nucleic-acid binding proteins regulating gene expression and are key drivers of GRN function. However, the combinatorial mechanisms by which the interactions between specific TFs and RBPs regulate gene expression remain largely unknown. To identify possible combinations of TFs and RBPs that may function together, developing a tool that compares and contrasts the interactions of multiple TFs and RBPs with nucleic acids to identify their common and unique targets is necessary. Ther

SUBMITTER: Mahableshwarkar P 

PROVIDER: S-EPMC11585304 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature