Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors.

ABSTRACT: Aggressive pituitary neuroendocrine tumors (PitNETs)/adenomas are characterized by progressive growth despite surgery and all standard medical therapies and radiotherapy. A subset will metastasize to the brain and/or distant locations and are termed metastatic PitNETs (pituitary carcinomas). Studies of potential prognostic markers have been limited due to the rarity of these tumors. A few recurrent somatic mutations have been identified, and epigenetic alterations and chromosomal rearrangements have not been explored in larger cohorts of aggressive and metastatic PitNETs. In this study, we performed genome-wide methylation analysis, including copy-number variation (CNV) calculations, on tumor tissue specimens from a large international cohort of 64 patients with aggressive (48) and metasta

SUBMITTER: Jotanovic J 

PROVIDER: S-EPMC11585505 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature