Hsa_circ_0072732 enhances sunitinib resistance of renal cell carcinoma by inhibiting ferroptosis.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is one of the most diagnosed urological malignancies with high mortality and increasing incidence. What's more, the sunitinib resistance undoubtedly increased the difficulties in RCC therapy. Circular RNAs (circRNAs) are a newly found type of non-coding RNAs with a special circular structure, and are found to participate in the occurrence development, chemoresistance, and prognosis of cancers. Ferroptosis regulates disease progression mainly via polyunsaturated fatty acid metabolism and glutamine catabolic pathways. The mechanism of circRNAs contributed to sunitinib resistance through ferroptosis has not been elucidated clearly.

Materials and methods

In our research, we identified a novel circRNA Hsa_circ_0072732 from circRNA datasets (G

SUBMITTER: Tian X 

PROVIDER: S-EPMC11585529 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature