Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes.

ABSTRACT: Glucokinase (GCK) is an essential enzyme for blood glucose homeostasis. Because of its importance in glucose metabolism, GCK is considered an attractive target for the development of antidiabetic drugs. However, a viable therapeutic agent has still to emerge, prompting efforts to improve understanding of the complex regulation and biological effects of GCK. Using the vertebrate organism zebrafish, an attractive model to study metabolic diseases and pharmacological responses, we dissected the complexities of gck regulation and unraveled effects of Gck modulation. We found that while gck expression in zebrafish islet cells is constitutive, gck expression in the liver is regulated by nutritional status, confirming similarity to the mammalian system. A combination of transgenic gck reporter li

SUBMITTER: Schmitner N 

PROVIDER: S-EPMC11585571 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature