Modeling early phenotypes of Parkinson's disease by age-induced midbrain-striatum assembloids.

ABSTRACT: Parkinson's disease, an aging-associated neurodegenerative disorder, is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Human in vitro models are enabling the study of the dopaminergic neurons' loss, but not the dysregulation within the dopaminergic network in the nigrostriatal pathway. Additionally, these models do not incorporate aging characteristics which potentially contribute to the development of Parkinson's disease. Here we present a nigrostriatal pathway model based on midbrain-striatum assembloids with inducible aging. We show that these assembloids can develop characteristics of the nigrostriatal connectivity, with catecholamine release from the midbrain to the striatum a

SUBMITTER: Barmpa K 

PROVIDER: S-EPMC11585662 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature