An in vitro-in silico workflow for predicting renal clearance of PFAS.

ABSTRACT: Per- and poly-fluoroalkyl substances (PFAS) have a wide range of elimination half-lives (days to years) in humans, thought to be in part due to variation in proximal tubule reabsorption. While human biomonitoring studies provide important data for some PFAS, renal clearance (CL_renal) predictions for hundreds of PFAS in commerce requires experimental studies with in vitro models and physiologically-based in vitro-to-in vivo extrapolation (IVIVE). Options for studying renal proximal tubule pharmacokinetics include cultures of renal proximal tubule epithelial cells (RPTECs) and/or microphysiological systems. This study aimed to compare CL_renal predictions for PFAS using in vitro models of varying complexity (96-well plates, static 24-well Transwells and a fluidic microph

SUBMITTER: Lin HC 

PROVIDER: S-EPMC11585971 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature