Identification and analysis of a cell communication prognostic signature for oral squamous cell carcinoma at bulk and single-cell levels.

ABSTRACT: Head and neck squamous cancer (HNSC) is a heterogenous malignant tumour disease with poor prognosis and has become the current major public health concern worldwide. Oral squamous cell carcinoma (OSCC) is the majority of HNSC. It is still in lack of comprehensive tumour immune microenvironment analysis and prognostic model development for OSCC's clinic practice. Single-cell sequencing data analysis was conducted to identify immune cell subtypes and illustrate cell-cell interaction status in OSCC via R package 'Seurat', 'Harmony', 'elldex' and 'CellChat'. Base on the bulk sequencing data, WGCNA analysis was employed to identify the CD8⁺ T cell related gene module. XGBoost was used to construct the gene prognostic model for OSCC. Validation sets and immunotherapy data sets were an

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11586053 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature