How conductivity boundaries influence the electric field induced by transcranial magnetic stimulation in in vitro experiments.

ABSTRACT:

Background

Although transcranial magnetic stimulation (TMS) has become a valuable method for non-invasive brain stimulation, the cellular basis of TMS activation of neurons is still not fully understood. In vitro preparations have been used to understand the biophysical mechanisms of TMS, but in many cases these studies have encountered substantial difficulties in activating neurons.

Objective/hypothesis

The hypothesis of this work is that conductivity boundaries can have large effects on the electric field in commonly used in vitro preparations. Our goal was to analyze the resulting difficulties in in vitro TMS using a simulation study, using a charge-based boundary element model.

Methods

We decomposed the total electric field into the sum of the primary electric fie

SUBMITTER: Sundaram P 

PROVIDER: S-EPMC11586064 | biostudies-literature | 2024 Sep-Oct

REPOSITORIES: biostudies-literature