Histoplasty Modification of the Tumor Microenvironment in a Murine Preclinical Model of Breast Cancer.

ABSTRACT:

Purpose

To develop a noninvasive therapeutic approach able to alter the biophysical organization and physiology of the extracellular matrix (ECM) in breast cancer.

Materials and methods

In a 4T1 murine model of breast cancer, histoplasty treatment with a proprietary 700-kHz multielement therapy transducer using a coaxially aligned ultrasound (US) imaging probe was used to target the center of an ex vivo tumor and deliver subablative acoustic energy. Tumor collagen morphology was qualitatively evaluated before and after histoplasty with second harmonic generation. Separately, mice bearing bilateral 4T1 tumors (n = 4; total tumors = 8) were intravenously injected with liposomal doxorubicin. The right flank tumor was histoplasty-treated, and tumors were fluorescently imaged to

SUBMITTER: Pieper AA 

PROVIDER: S-EPMC11586070 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature