Potential Metabolite Biomarkers of Multiple Sclerosis from Multiple Biofluids.

ABSTRACT: Multiple sclerosis (MS) is a chronic and progressive neurological disorder without a cure, but early intervention can slow disease progression and improve the quality of life for MS patients. Obtaining an accurate diagnosis for MS is an arduous and error-prone task that requires a combination of a detailed medical history, a comprehensive neurological exam, clinical tests such as magnetic resonance imaging, and the exclusion of other possible diseases. A simple and definitive biofluid test for MS does not exist, but is highly desirable. To address this need, we employed NMR-based metabolomics to identify potentially unique metabolite biomarkers of MS from a cohort of age and sex-matched samples of cerebrospinal fluid (CSF), serum, and urine from 206 progressive MS (PMS) patients, 46 relaps

SUBMITTER: Bhinderwala F 

PROVIDER: S-EPMC11586083 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature