Context-dependent role of group 3 innate lymphoid cells in mucosal protection.

ABSTRACT: How group 3 innate lymphoid cells (ILC3s) regulate mucosal protection in the presence of T cells remains poorly understood. Here, we examined ILC3 function in intestinal immunity using ILC3-deficient mice that maintain endogenous T cells, T helper 17 (T_H17) cells, and secondary lymphoid organs. ILC3s were dispensable for generation of T_H17 and T_H22 cell responses to commensal and pathogenic bacteria, and absence of ILC3s did not affect IL-22 production by CD4 T cells before or during infection. However, despite the presence of IL-22-producing T cells, ILC3s and ILC3-derived IL-22 were required for maintaining homeostatic functions of the intestinal epithelium. T cell-sufficient, ILC3-deficient mice were capable of pathogen clearance and survived infection w

SUBMITTER: Araujo LP 

PROVIDER: S-EPMC11586228 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature