CXCR6 expression predicts prognosis and immunotherapeutic benefit in muscle-invasive bladder cancer.

ABSTRACT:

Background

Increasing evidence suggests that the CXC chemokine receptor 6 (CXCR6) is involved in tumor progression and the regulation of tumor immunity. However, its role in muscle-invasive bladder cancer (MIBC) remains largely unexplored.

Methods

Data from 391 MIBC patients in the TCGA, 212 patients from GEO, 131 patients from our center, 195 patients in the IMvigor210 cohort, and single-cell RNA sequencing (scRNA-seq) data from 9 bladder cancer patients (GSE222315) were analyzed. Additionally, data from the GEPIA 2, TISCH2, TIMER2.0, and UALCAN platforms were utilized to investigate the prognostic and immunotherapeutic significance of CXCR6 in MIBC.

Results

We observed that CXCR6 expression was significantly reduced in bladder cancer tumors and correlated with tumor

SUBMITTER: Lu X 

PROVIDER: S-EPMC11586233 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature