FCGBP functions as a tumor suppressor gene in head and neck squamous cell carcinoma.

ABSTRACT:

Purpose

The pathogenesis of head and neck squamous cell carcinoma (HNSCC) was complex and the overall survival was not satisfying. It was urgent to uncover novel molecules that play vital role in HNSCC for disease monitoring and drug development.

Methods

Distinguished expression of FCGBP mRNA in HNSCC was analyzed by TCGA-HNSC and three GEO datasets, the relationship between FCGBP and clinical stage and survival was analyzed by GEPIA 2, the immune infiltration pattern analysis was conducted by TIMER 2.0, pathways affected by FCGBP was conducted by GSEA and GO/KEGG. In vitro experiments (including qRT-PCR, siRNA transfection, CCK8, transwell assay and flow cytometry) were conducted to confirm bioinformatic analysis.

Results

FCGBP was down-regulated in tumor samples com

SUBMITTER: Zeng L 

PROVIDER: S-EPMC11586324 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature