Gut microbiota and metabolic profiles in adults with unclassified diabetes: a cross-sectional study.

ABSTRACT:

Aims

Our study, employing a multi-omics approach, aimed to delineate the distinct gut microbiota and metabolic characteristics in individuals under 30 with unclassified diabetes, thus shedding light on the underlying pathophysiological mechanisms.

Methods

This age- and sex-matched case-control study involved 18 patients with unclassified diabetes, 18 patients with classic type 1 diabetes, 13 patients with type 2 diabetes, and 18 healthy individuals. Metagenomics facilitated the profiling of the gut microbiota, while untargeted liquid chromatography-mass spectrometry was used to quantify the serum lipids and metabolites.

Results

Our findings revealed a unique gut microbiota composition in unclassified diabetes patients, marked by a depletion of Butyrivibrio proteocl

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11586653 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature