HPLC-Based Automated Synthesis and Purification of Carbohydrates.

ABSTRACT: Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.

SUBMITTER: Kashiwagi GA 

PROVIDER: S-EPMC11586687 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature