Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports.

ABSTRACT:

Background

Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology.

Methods

Clinical trial reports of sildenafil for erectile dysfunction from September 1997 were used for meta-analysis of randomised trials (at least four weeks duration) and using fixed or dose optimisation regimens. The main outcome sought was an erection, sufficiently rigid for penetration, followed by successful intercourse, and conducted at home.

Results

Ten randomised controlled trials fulfilled the inclusion criteria (2123 men given sildenafil and 1131 placebo). NNT or NNH were calculated for important efficacy, adverse event and discontinuation outcomes. Dose optimisation led to at least 60% of attempts at sexua

SUBMITTER: Moore RA 

PROVIDER: S-EPMC115867 | biostudies-literature | 2002 May

REPOSITORIES: biostudies-literature