Occurrence of leu+ revertants under starvation cultures in Escherichia coli is growth-dependent.

ABSTRACT:

Background

Many investigations have reported that advantageous mutations occurred more frequently under selective conditions than those under non-selective conditions. This phenomenon is referred to as adaptive mutation. Their characteristics are that adaptive mutations are directed and growth-independent. The idea of directed adaptive mutation had been objected by some reports, however, the idea of growth-independent adaptive mutation has been held till today.

Results

In this paper, we have observed that under leucine starvation conditions, leu+ revertants accumulated as a function of time; leu- to leu+ reverse mutation rates and frequencies were higher than those under non starvation conditions; and no divided cells could be monitored by the penicillin method. These result

SUBMITTER: Jin J 

PROVIDER: S-EPMC115868 | biostudies-literature | 2002 Apr

REPOSITORIES: biostudies-literature