Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction.

ABSTRACT:

Background

Persistent airflow obstruction (PAO) in patients with asthma can be difficult to treat. Tezepelumab blocks thymic stromal lymphopoietin, an epithelial cytokine implicated in asthma pathogenesis. This analysis evaluated the efficacy of tezepelumab in patients with severe, uncontrolled asthma and PAO.

Methods

PATHWAY (phase 2b) and NAVIGATOR (phase 3) were multicentre, randomised, double-blind, placebo-controlled studies. This post hoc analysis included PATHWAY and NAVIGATOR patients who received tezepelumab 210 mg or placebo every 4 weeks for 52 weeks. Change from baseline to week 52 in pre-bronchodilator forced expiratory volume in 1 s (FEV₁) and the annualised asthma exacerbation rate (AAER) over 52 weeks were assessed in patients with and witho

SUBMITTER: Israel E 

PROVIDER: S-EPMC11587167 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature