Dissecting the genetic admixture and forensic signatures of ethnolinguistically diverse Chinese populations via a 114-plex NGS InDel panel.

ABSTRACT: Comprehensive characterizations of genetic diversity and demographic models of ethnolinguistically diverse Chinese populations are essential for elucidating their forensic characteristics and evolutionary past. We developed a 114-plex NGS InDel panel to genotype 114 genome-wide markers and investigated the genetic structures of Zhuang, Hui, Miao, Li, Tibetan, Yi, and Mongolian populations, encompassing five language families. This panel demonstrated robust performance, with exceptional potential for forensic individual identification and paternity testing, evidenced by the combined power of discrimination for 77 autosomal InDels (ranged from 1-3.6400 × 10^-30 to 1-3.5713 × 10^-32) and the combined power of exclusion (ranged from 1-2.1863 × 10^-6 to 1-2.1261 × 

SUBMITTER: Yang C 

PROVIDER: S-EPMC11587575 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature