ZDHHC7-mediated <i>S</i>-palmitoylation of ATG16L1 facilitates LC3 lipidation and autophagosome formation.

ABSTRACT: Macroautophagy/autophagy is a fundamental cellular catabolic process that delivers cytoplasmic components into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their contents are degraded. Autophagy recycles cytoplasmic components, including misfolded proteins, dysfunctional organelles and even microbial invaders, thereby playing an essential role in development, immunity and cell death. Autophagosome formation is the main step in autophagy, which is governed by a set of ATG (autophagy related) proteins. ATG16L1 interacts with ATG12-ATG5 conjugate to form an ATG12-ATG5-ATG16L1 complex. The complex acts as a ubiquitin-like E3 ligase that catalyzes the lipidation of MAP1LC3/LC3 (microtubule associated protein 1 light chain 3), which is crucial for autophagos

SUBMITTER: Wei F 

PROVIDER: S-EPMC11587844 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature