The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor.

ABSTRACT: The glucocorticoid and mineralocorticoid receptors (GR and MR, respectively) have distinct, yet overlapping physiological and pathophysiological functions. There are indications that both receptors interact functionally and physically, but the precise role of this interdependence is poorly understood. Here, we analyzed the impact of GR coexpression on MR genome-wide transcriptional responses and chromatin binding upon activation by aldosterone and glucocorticoids, both physiological ligands of this receptor. Transcriptional responses of MR in the absence of GR result in fewer regulated genes. In contrast, coexpression of GR potentiates MR-mediated transcription, particularly in response to aldosterone, both in cell lines and in the more physiologically relevant model of mouse colon organoi

SUBMITTER: Johnson TA 

PROVIDER: S-EPMC11588051 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature