Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum.

ABSTRACT: Reactive inhibitory control is crucial for survival. Traditionally, this control in mammals was attributed solely to the hyperdirect pathway, with cortical control signals flowing unidirectionally from the subthalamic nucleus (STN) to basal ganglia output regions. Yet recent findings have put this model into question, suggesting that the STN is assisted in stopping actions through ascending control signals to the striatum mediated by the external globus pallidus (GPe). Here, we investigate this suggestion by harnessing a biologically constrained spiking model of the cortico-basal ganglia-thalamic (CBGT) circuit that includes pallidostriatal pathways originating from arkypallidal neurons. Through a series of experiments probing the interaction between three critical inhibitory nodes (the ST

SUBMITTER: Giossi C 

PROVIDER: S-EPMC11588131 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature