The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation.

ABSTRACT: The sebaceous gland (SG) is a vital appendage of the epidermis, and its normal homeostasis and function is crucial for effective maintenance of the skin barrier. Notch signaling is a well-known regulator of epidermal differentiation, and has also been shown to be involved in postnatal maintenance of SGs. However, the precise role of Notch signaling in regulating SG differentiation in the adult homeostatic skin remains unclear. While there is evidence to suggest that Notch1 is the primary Notch receptor involved in regulating the differentiation process, the ligand remains unknown. Using monoclonal therapeutic antibodies designed to specifically inhibit of each of the Notch ligands or receptors, we have identified the Jag2/Notch1 signaling axis as the primary regulator of sebocyte different

SUBMITTER: Abidi SNF 

PROVIDER: S-EPMC11588336 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature