Noisy neuronal populations effectively encode sound localization in the dorsal inferior colliculus of awake mice.

ABSTRACT: Sound location coding has been extensively studied at the central nucleus of the mammalian inferior colliculus (CNIC), supporting a population code. However, this population code has not been extensively characterized on the single-trial level with simultaneous recordings or at other anatomical regions like the dorsal cortex of inferior colliculus (DCIC), which is relevant for learning-induced experience dependent plasticity. To address these knowledge gaps, here we made in two complementary ways large-scale recordings of DCIC populations from awake mice in response to sounds delivered from 13 different frontal horizontal locations (azimuths): volumetric two-photon calcium imaging with ~700 cells simultaneously recorded at a relatively low temporal resolution, and high-density single-unit

SUBMITTER: Boffi JC 

PROVIDER: S-EPMC11588337 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature