Autonomic reactivity to mental stress is associated with cardiovascular mortality.

ABSTRACT:

Aims

The mechanisms linking acute psychological stress to cardiovascular disease (CVD) mortality are incompletely understood. We studied the relationship of electrocardiographic measures of autonomic dysfunction during acute mental stress provocation and CVD death.

Methods and results

In a pooled cohort of 765 participants with stable CVD from two related studies, we collected Holter data during standardized laboratory-based mental stress testing with a speech task and followed them for events. We assessed autonomic function using low-frequency (LF) heart rate variability (HRV) in 5-min intervals before, during, and after stress induction, and specifically examined changes from rest to stress. We employed cause-specific survival models to examine its association with CVD and

SUBMITTER: Shah AS 

PROVIDER: S-EPMC11588410 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature