Another-regulin regulates cardiomyocyte calcium handling via integration of neuroendocrine signaling with SERCA2a activity.

ABSTRACT: Calcium (Ca²⁺) dysregulation is a hallmark feature of cardiovascular disease. Intracellular Ca²⁺ regulation is essential for proper heart function and is controlled by the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA2a). Another-regulin (ALN) is a newly discovered cardiomyocyte-expressed SERCA2a inhibitor, suggesting cardiomyocyte Ca²⁺-handling is more complex than previously appreciated. To study the role of ALN in cardiomyocytes, we generated ALN null mice (knockout, KO) and found that cardiomyocytes from these animals displayed enhanced Ca²⁺ cycling and contractility compared to wildtype (WT) mice, indicating enhanced SERCA2a activity. In vitro and in vivo studies show that ALN is post-translationally modified via phosphorylation

SUBMITTER: Hassel KR 

PROVIDER: S-EPMC11588527 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature