Cutaneous T cell lymphoma atlas reveals malignant T_H2 cells supported by a B cell-rich tumor microenvironment.

ABSTRACT: Cutaneous T cell lymphoma (CTCL) is a potentially fatal clonal malignancy of T cells primarily affecting the skin. The most common form of CTCL, mycosis fungoides, can be difficult to diagnose, resulting in treatment delay. We performed single-cell and spatial transcriptomics analysis of skin from patients with mycosis fungoides-type CTCL and an integrated comparative analysis with human skin cell atlas datasets from healthy and inflamed skin. We revealed the co-optation of T helper 2 (T_H2) cell-immune gene programs by malignant CTCL cells and modeling of the tumor microenvironment to support their survival. We identified MHC-II⁺ fibroblasts and dendritic cells that can maintain T_H2 cell-like tumor cells. CTCL tumor cells are spatially associated with B cel

SUBMITTER: Li R 

PROVIDER: S-EPMC11588665 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature