Circulating serum miRNAs predict response to platinum chemotherapy in high-grade serous ovarian cancer.

ABSTRACT:

Background

Platinum chemotherapy is the cornerstone of treatment for high-grade serous ovarian cancer (HGSOC); however, validated biomarkers that can accurately predict platinum response are lacking. Based on their roles in the underlying pathophysiology, circulating microRNAs are potential, noninvasive biomarkers in cancer. In the present study, we aimed to evaluate the circulating miRNA profiles of patients with HGSOC and to assess their potential utility as biomarkers to predict platinum response.

Methods

Pretreatment serum samples collected from patients who received platinum chemotherapy for Stage III-IV HGSOC between 2008 and 2016 were analyzed using miRNA microarray. LASSO logistic regression analysis was used to construct predictive models for treatment-free interval

SUBMITTER: Suzuki K 

PROVIDER: S-EPMC11588858 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature