Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization study.

ABSTRACT:

Background

Several blood proteins might be associated with the development of colorectal cancer (CRC), but many studies on this topic are often biased. By using genetic variation data, which is less influenced by environmental factors, we can better determine the causal relationship between specific blood proteins and the occurrence of colorectal cancer.

Methods

Data from a genome-wide association study (GWAS) on blood proteins, encompassing 1,478 proteins, and colorectal cancer (CRC) GWAS data, covering 637,693 subjects, were collected and organized. Additionally, GWAS data for obesity, diabetes mellitus (DM), and smoking were obtained for further analysis. Single nucleotide polymorphisms (SNPs) significantly associated with the exposure factors (blood proteins) were select

SUBMITTER: Xu W 

PROVIDER: S-EPMC11589031 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature