Identification of a 5-gene signature panel for the prediction of prostate cancer progression.

ABSTRACT:

Background

Despite nearly 100% 5-year survival for localised prostate cancer, the survival rate for metastatic prostate cancer significantly declines to 32%. Thus, it is crucial to identify molecular indicators that reflect the progression from localised disease to metastatic prostate cancer.

Methods

To search for molecular indicators associated with prostate cancer metastasis, we performed proteomic analysis of rapid autopsy tissue samples from metastatic prostate cancer (N = 8) and localised prostate cancer (N = 2). Then, we utilised multiple independent, publicly available prostate cancer patient datasets to select candidates that also correlate with worse prostate cancer clinical prognosis.

Results

We identified 154 proteins with increased expressions in metastase

SUBMITTER: Shen M 

PROVIDER: S-EPMC11589118 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature