Mechanisms of Shufeng Jiedu Capsule in treating bacterial pneumonia based on network pharmacology and experimental verification.

ABSTRACT:

Objective

The aim of this study was to investigate the underlying mechanism of Shufeng Jiedu Capsule (SFJD) for treating bacterial pneumonia (BP) in vivo based on network pharmacology and experimental verification study.

Methods

Network pharmacology was used to screen the active compounds and target genes of SFJD. Then, the multi drug resistance-Pseudomonas aeruginosa (MDR-PA) mice lethal model and MDR-PA pneumonia model were established to evaluate the therapeutic effects and underlying mechanisms of SFJD. Western blot and ELISA were used to determinate the protein expression level of the IL-17 signaling pathway and JAK/STAT signaling pathway.

Results

After screening, 172 potential components of SFJD were generated, based on which we constructed an SFJD

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11589334 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature