Crucial immunological roles of the invasion front in innate and adaptive immunity in cervical cancer.

ABSTRACT:

Background

The immunostimulatory actions of innate and adaptive immune responses play a crucial role in the cancer-immunity cycle. Although cervical cancer (CC) exhibits a high recurrence rate, the relation with lymphocytes in the tumor tissue have not been analyzed.

Methods

We analyzed NKT, NK, and T cells, not only in peripheral blood (PB), but also tumor tissue through histological analysis from 23 patients with CC collected before treatment. A correlation of them between PB and the tumor tissue were assessed.

Results

We detected functional NKT and NKG2D^hi NK cells and effector CD4⁺ Tregs in PB. In the tumor, we detected the infiltration of LAG-3⁺ TIM-3⁺ CD4⁺ and CD8⁺ T cells rather than NK cells par

SUBMITTER: Hirahara Y 

PROVIDER: S-EPMC11589768 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature